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Functioning as a transcription factor, TP53 orchestrates intrinsic apoptosis by dampening the presence of survival proteins such as MCL1, MYC, and BCL2, while elevating pro-apoptotic genes such as BAX in colorectal cancer cells [121, 122]

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As Secretary, Andrus served a critical role in the passage of Arizonas 1980 Groundwater Management Act, serving as the foil for then-Governor Bruce Babbitt